A blister, which is also called a vesicle by medical professionals, is a small pocket of body fluid (lymph, serum, plasma, blood or pus) within the upper layers of the skin. Blisters are typically caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection.

Blisters commonly develop on the feet. Most blisters are filled with a clear fluid, either serum or plasma. Sometimes they are filled with blood. They can also contain pus when become infected.

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